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Last Updated: a year ago

Possible Interaction: Carbon Monoxide and Heme Iron

supplement:

Heme Iron

Research Papers that Mention the Interaction

CO binds to the heme iron of most hemoproteins.
BioEssays : news and reviews in molecular, cellular and developmental biology  •  2004  |  View Paper
CO impedes oxygen supply via haemoglobin by binding with high affinity to heme iron and interferes with enzymes that use heme as prosthetic group.
European Journal of Epidemiology  •  2015  |  View Paper
It is well known that CO has a higher affinity for heme iron than does molecular oxygen (O(2)); therefore, CO is potentially toxic.
Biochemistry  •  2012  |  View Paper
Carbon monoxide CO ) also binds after reduction of the heme iron.
Journal of Biological Chemistry  •  2004  |  View Paper
Unexpectedly, the binding of CO to heme iron is found to result in a major conformational change at CuB, which now binds only two equidistant histidine imidazoles at 1.95 A and a chloride ion at 2.
Biochemistry  •  1999  |  View Paper
Remarkably, CO bound to the heme iron is tilted by ~30° with respect to the heme normal, which contrasts to the situation in myoglobin and in present FixLH-CO X-ray crystal structure models.
Journal of the American Chemical Society  •  2011  |  View Paper
Density-functional calculations demonstrate that indeed vibrational frequency and absorption strength are not linearly coupled and that the absorption strength varies in a slower manner due to charge transfer from the heme iron to CO.
Physical review letters  •  2004  |  View Paper
Furthermore, stopped-flow kinetics under high pressure show that CO binding to the heme iron is hindered by substrate in NOS, but not in BM3.
Journal of inorganic biochemistry  •  2001  |  View Paper
This suggests a delicate balance between five- and six-coordinate heme iron in both NO and CO complexes.
Methods  •  1999  |  View Paper
On the other hand, the … recombination of the dissociated CO … heme iron was significantly different between these two forms; the recombination rate constants were 1.1 X 10(3) and 3.… X 10(4) M-1 S-1 at 25 degrees C for the acidic and alkaline forms, respectively.
The Journal of biological chemistry  •  1985  |  View Paper