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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbon Monoxide
supplement:
Glycerol
Research Papers that Mention the Interaction
“ Carbon monoxide inhibited glycerol oxidation indicating a requirement for cytochrome P-450.”
Oxidation of glycerol to formaldehyde by rat liver microsomes.“Maximal change of redox state was observed during ventilation with carbon monoxide ; surface fluorescence increased 6.6%, lactate/pyruvate increased 5.8 times, glycerol 3-P/dihydroxyacetone-P increased fourfold and glutamate/alpha-ketoglutarate doubled.”
“When glycerol served as substrate, neither Ca 2+ or H + enhanced gluconeogenesis, but both inhibited CO 2 production from glycerol.”
“The extraction buffer required … of sucrose or glycerin and dithiothreitol to obtain an active hydroxylase that retained its activity on storage at -70 degrees C. Enzymic activity required …(2) and NADPH, was optimum at pH 8.5 and 30 degrees C, and could be inhibited 79% by carbon monoxide.”
Microsomal flavonoid 3'-monooxygenase from maize seedlings.
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