Possible Interaction: Carbon Monoxide and Glutathione

“We have … stress‐inducible CO in and around cancer cells suppresses CBS to result in decreased methylation of PFKFB3, the enzyme regulating PFK‐1, leading … of glucose biotransformation from glycolysis toward pentose phosphate pathway; such a metabolic remodeling causes chemoresistance through increasing NADPH and reduced glutathione under stress … cells.”

“In conclusion, CO improves neuronal differentiation of SH-S5Y5 cells by stimulating the PPP and modulating the GSH system.”

“ CO also increased the cytokines and lipid peroxidation (LPO) in serum, and myeloperoxidase (MPO) activity and LPO in recto-anal tissues, and reduced the GSH , CAT, GPx, and SOD levels in serum and recto-anal tissues.”

“Conclusion: The present study demonstrated that CO enhanced biliary output in conjunction with NO by increasing the biliary excretion of glutathione.”

“… glutathione depletion and P450 loss were almost completely … saturation of the incubation mixture with CO and were partially prevented by the presence of the free-radical scavenger N-t-butyl-alpha-phenylnitrone … carbene trapping agent 2,3-dimethyl-2-butene, suggesting that both types of intermediates may be involved.”

“The block of the oxidative pathway with carbon monoxide prevents glutathione content depletion, and shows that this conjugation is the major step in 1,2-dichloropropane metabolism.”

“Meanwhile, CO pretreatment modulated several enzymes responsible for GSH metabolism, thus resulting in the partial restoration of GSH : GSSG ratio, which was significantly blocked by Hb.”