Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Carbon Monoxide and Glutathione

Research Papers that Mention the Interaction

We have … stress‐inducible CO in and around cancer cells suppresses CBS to result in decreased methylation of PFKFB3, the enzyme regulating PFK‐1, leading … of glucose biotransformation from glycolysis toward pentose phosphate pathway; such a metabolic remodeling causes chemoresistance through increasing NADPH and reduced glutathione under stress … cells.
Microcirculation  •  2016  |  View Paper
In conclusion, CO improves neuronal differentiation of SH-S5Y5 cells by stimulating the PPP and modulating the GSH system.
Redox biology  •  2018  |  View Paper
CO also increased the cytokines and lipid peroxidation (LPO) in serum, and myeloperoxidase (MPO) activity and LPO in recto-anal tissues, and reduced the GSH , CAT, GPx, and SOD levels in serum and recto-anal tissues.
Journal of food biochemistry  •  2020  |  View Paper
Conclusion: The present study demonstrated that CO enhanced biliary output in conjunction with NO by increasing the biliary excretion of glutathione.
Journal of the Chinese Medical Association : JCMA  •  2013  |  View Paper
glutathione depletion and P450 loss were almost completely … saturation of the incubation mixture with CO and were partially prevented by the presence of the free-radical scavenger N-t-butyl-alpha-phenylnitrone … carbene trapping agent 2,3-dimethyl-2-butene, suggesting that both types of intermediates may be involved.
Toxicology and applied pharmacology  •  1997  |  View Paper
The block of the oxidative pathway with carbon monoxide prevents glutathione content depletion, and shows that this conjugation is the major step in 1,2-dichloropropane metabolism.
Human & experimental toxicology  •  1993  |  View Paper
Meanwhile, CO pretreatment modulated several enzymes responsible for GSH metabolism, thus resulting in the partial restoration of GSH : GSSG ratio, which was significantly blocked by Hb.
The New phytologist  •  2008  |  View Paper