Possible Interaction: Carbon Monoxide and Glucose

“A decrease in production of carbon monoxide was seen after glucose given orally as well as intravenously, whereas total serum bilirubin decreased significantly only after glucose orally.”

“We also show, for the first time, that glucose markedly stimulates the HO activity ( CO production) in intact islets.”

“3) At 20 degrees C, glucose addition to ST solution increased % CO to 76.5 +/- 2.4% from 57.7 +/- 3.8% in glucose-free ST solution group (p < 0.05).”

“However, at 4 degrees C, glucose addition to ST solution was rather harmful and decreased % CO to 61.4 +/- 2.8% from 74.4 +/- 2.2 in glucose-free ST solution group (p < 0.05). (”

“Recovery hyperglycemia was, in turn, correlated (r = 0.69, P less than 0.001) with the fall in glucose during the second half of CO exposure.”

“… glucose resulted in … 14 CO 2 from the oxidation of [1- 14 C] glucose/ relative molar specific radioactivity of 14 CO 2 from the oxidation of [6- … concentration of 82 mg % to 4·6 at 240 mg %, reflecting an overall decrease in the oxidation of [1- 14 C] glucose.”

“Endogenous CO affects energy metabolism, regulates the utilization of glucose and addresses CYP450 enzymes.”

“Incubation of roots with organic substrates (e.g., 5 mM syringic acid, glucose , alanine, and acetate) dramatically reduced the rate of CO consumption, perhaps reflecting a shift in metabolism by facultative CO oxidizers.”

“14 CO 2 production was not decreased by starvation when pyruvate or acetate served as substrates, but was inhibited by 90% with glucose.”