Possible Interaction: Carbon Monoxide and Calcium Supplement

“Furthermore, CO inhibited UTP-induced increases in calcium and Cl- secretion, and forskolin-induced increases in cAMP and Cl- secretion.”

“In addition, CO from CORM‐401 increases mitochondrial calcium and activates complexes I and II.”

“We conclude that CO inhibits TGF acting downstream from depolarization and calcium entry , acting via cGMP at low concentrations, but additional mechanisms of action may be involved at higher concentrations.”

“In isolated non-synaptic mitochondria, CO partially inhibits (i) loss of potential, (ii) the opening of a nonspecific pore through the inner membrane, (iii) swelling, and (iv) cytochrome c release, which are induced by calcium , diamide, or atractyloside (a ligand of ANT).”

“Mn or Co markedly suppressed the restorative effects of Ca or Sr.”

“SummaryAccording to earlier studies on mammalian papillary muscles, Ni and Co ions reduce the Ca dependent mechanical response whilst the action potential persists.”

“The following results were obtained:1.Ni ions (2 mM) and Co ions (2 mM) strongly depress the Ca conductivity of the membrane.”

“b) Co-induced replacement of the slow Ca … fast inward current component, c) synergetic effects of Co … Ca in restricting the fast Na current.4.The selective inhibition of the transmembrane Ca conductivity clearly … separate channel for Ca which is independent from the fast Na channel of the membrane.”

“Although it did not increase the resting level of intracellular free calcium concentration, CO significantly enhanced the calcium sensitivity of single KCa channels in SMCs.”

“ CO reduced Ca++ concentrations significantly (P less than 0.01) by 29% to 369 +/- 18 mM/g tissue.”

“Addition of Co (2.5 mM) reduced the amplitude of both Ca and Ba currents but slowed the inactivation of only the Ca current.”

“These findings are consistent with physiological observations that suggest that Mg 2+ and Co 2 + act at different sites in modifying the actions of Ca 2 + at synapses.”