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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carbidopa and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

When L-tryptophan or 5-hydroxytryptophan is administered with phenelzine (a monoamine oxidase inhibitor) and carbidopa (a selective peripheral L-amino acid decarboxylase inhibitor) to raise brain serotonin, a significant increase in myocardial electrical stability is observed.
Federation proceedings  •  1986  |  View Paper
These measures were made on two drug-free baseline days and on two days when the subjects had been receiving the peripheral decarboxylase inhibitor, carbidopa , which inhibits tryptophan metabolism via extracerebral indoleamine pathways.
Archives of general psychiatry  •  1976  |  View Paper
2) In hepatocytes incubated with a low physiological concentration (0.1 mM) of tryptophan, carbidopa (5 × 10 −5 M) produced a significant inhibiton of kynureninase activity.
Biochemical pharmacology  •  1981  |  View Paper