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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Carbidopa and Melatonin



Research Papers that Mention the Interaction

Carbidopa , in a dose-dependent manner, attenuated or completely prevented MDL-induced stimulation of melatonin biosynthesis in the pineal gland located outside the blood-brain-barrier.
Journal of neural transmission. Supplementum  •  1994  |  View Paper
In these experiments, rats were treated with a dose of the aromatic amino acid decarboxylase inhibitor, carbidopa , that was sufficient to inhibit the synthesis of pineal serotonin and melatonin but not brain serotonin (Oxenkrug et al. 1984b).
Biological Psychiatry  •  1985  |  View Paper
Carbidopa , an aromatic acid decarboxylase inhibitor, has been shown to significantly decrease the pineal concentration of melatonin , N‐acetyl serotonin (NAS), serotonin (5‐HT), and 5‐hydroxyindoleacetic acid (5‐HIAA) but not the hypothalamic concentrations of these indoles.
Journal of pineal research  •  1984  |  View Paper