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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carbidopa and Epigallocatechin Gallate

Research Papers that Mention the Interaction

Conclusions/Significance These observations suggest that oral administration of EGCG may have significant beneficial effects in Parkinson's patients treated with L-DOPA and carbidopa by exerting a modest inhibition of L-DOPA methylation plus a strong neuroprotection against oxidative damage and degeneration.
EGCG strongly inhibited human liver COMT-mediated O-methylation of L-DOPA in a concentration-… in vitro, with an average IC 50 of 0.36 µM. Oral administration of EGCG moderately lowered the accumulation of 3-O-methyldopa in … plasma and striatum of rats treated with L-DOPA + carbidopa.
PloS one  •  2010  |  View Paper