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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carbenoxolone and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

CBX treatment led to a gradual decrease in both basal and in corticotropic releasing hormone (CRH)-stimulated plasma ACTH concentrations and CRH-stimulated serum cortisol concentrations, without side effects.
The findings suggest that CBX inhibits ACTH secretion from canine pituitary tumors, resulting in lower cortisol concentrations.
We previously reported that carbenoxolone (CBX), an inhibitor of 11HSD, suppressed ACTH secretion from the pituitary gland, and decreased cortisol concentrations in healthy dogs.
PloS one  •  2016  |  View Paper
The results of this study suggested that CBX inhibits ACTH secretion from pituitary due to altered 11HSD expressions, and is potentially useful for the treatment of canine Cushing’s disease.
PloS one  •  2015  |  View Paper