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Last Updated: a year ago

Possible Interaction: Carbamazepine and Vitamin D

supplement:

Vitamin D

Research Papers that Mention the Interaction

Evidence suggests that carbamazepine affects bone metabolism by altering vitamin D status.
Pediatric neurology  •  2010  |  View Paper
These changes were accompanied by an increased serum RANKL with all AEDs while vitamin D levels were reduced only with CBZ treatment and P1NP levels were reduced with SVP and CBZ.
Bone  •  2018  |  View Paper
carbamazepine concentrations with albumin (B = -0.300, p = 0.040), calcium (B = -0.262, p = 0.004), phosphorus (B = -0.241, p = 0.022), … = 0.003), RBC (B = -0.257, p = 0.001), NEU% (B = -0.289, p = <0.001), LYM% (B = -0.268, p = 0.001), D vitamini (….
Journal of pharmaceutical and biomedical analysis  •  2021  |  View Paper
CBZ use causes poor bone quality through vitamin D metabolism.
Nigerian journal of clinical practice  •  2020  |  View Paper
Results Levels of vitamin D (standardized mean difference [SMD]: −0.62, 95% CI: −0.89 to −0.35) and calcium (SMD: −0.38, 95% CI: −0.67 to −0.09) were significantly lower in the CBZ group than controls.
The Journal of international medical research  •  2020  |  View Paper
Results: The average value of vitamin D in serum was significantly lower in CBZ group than in control group (Vit D 17.03+12.86 vs. 32.03+6.99, p=0.0001).
Medical archives  •  2018  |  View Paper
Carbamazepine caused a significant decrease in BMD, which was accompanied by a decrease in the level of vitamin D (25-OHD(3)).
Epilepsy & Behavior  •  2007  |  View Paper
Serum 25-hydroxyvitamin D of the carbamazepine-treated group (9.8 +/- 3.2 microg/l) was significantly lower than the other groups (15.1 +/- 3.5, 16.6 +/- 4.7 microg/l, respectively).
Valproic acid and carbamazepine therapy results in a hyperparathyroid state and altered vitamin D metabolism, respectively.
Journal of pediatric endocrinology & metabolism : JPEM  •  2006  |  View Paper
It is still not completely clear whether or not carbamazepine CBZ ) causes alterations in vitamin D status and in bone metabolism.
Calcified Tissue International  •  2003  |  View Paper
Enzyme-inducing AEDs (phenytoin, carbamazepine , primidone and phenytoin) increase vitamin D metabolism due to induction of cytochrome P450.
Archives of Disease in Childhood  •  2020  |  View Paper
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