Possible Interaction: Carbamazepine and Vitamin D

“Evidence suggests that carbamazepine affects bone metabolism by altering vitamin D status.”

“These changes were accompanied by an increased serum RANKL with all AEDs while vitamin D levels were reduced only with CBZ treatment and P1NP levels were reduced with SVP and CBZ.”

“… carbamazepine concentrations with albumin (B = -0.300, p = 0.040), calcium (B = -0.262, p = 0.004), phosphorus (B = -0.241, p = 0.022), … = 0.003), RBC (B = -0.257, p = 0.001), NEU% (B = -0.289, p = <0.001), LYM% (B = -0.268, p = 0.001), D vitamini (….”

“ CBZ use causes poor bone quality through vitamin D metabolism.”

“Results Levels of vitamin D (standardized mean difference [SMD]: −0.62, 95% CI: −0.89 to −0.35) and calcium (SMD: −0.38, 95% CI: −0.67 to −0.09) were significantly lower in the CBZ group than controls.”

“Results: The average value of vitamin D in serum was significantly lower in CBZ group than in control group (Vit D 17.03+12.86 vs. 32.03+6.99, p=0.0001).”

“ Carbamazepine caused a significant decrease in BMD, which was accompanied by a decrease in the level of vitamin D (25-OHD(3)).”

“Serum 25-hydroxyvitamin D of the carbamazepine-treated group (9.8 +/- 3.2 microg/l) was significantly lower than the other groups (15.1 +/- 3.5, 16.6 +/- 4.7 microg/l, respectively).”

“Valproic acid and carbamazepine therapy results in a hyperparathyroid state and altered vitamin D metabolism, respectively.”

“It is still not completely clear whether or not carbamazepine CBZ ) causes alterations in vitamin D status and in bone metabolism.”

“Enzyme-inducing AEDs (phenytoin, carbamazepine , primidone and phenytoin) increase vitamin D metabolism due to induction of cytochrome P450.”