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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbamazepine
supplement:
Melatonin
Research Papers that Mention the Interaction
“In conclusion, these observations suggest that CBZ monotherapy may lead to chromosome damaging effects (genotoxic) and the use of melatonin as anti-mutagenic agent for human protection against CBZ-induced chromosome damage should be considered.”
In vivo and in vitro evaluation of the mutagenic potential of carbamazepine: does melatonin have anti-mutagenic activity?“Pretreating the animals with diazepam, carbamazepine or lamotrigine enhanced the anticonvulsant effect of melatonin.”
Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures.“ Melatonin at the subconvulsive dose of 25 mg/kg potentiated the anticonvulsive activity of carbamazepine and phenobarbital (ED50 values were significantly decreased from 12.1 to 8.3 and from 18.9 to 11.8 mg/kg, respectively).”
“Regarding pharmacodynamic interaction, Xiao-yao-san, melatonin , and alcohol increased the side effects of CBZ while caffeine lowered the antiepileptic efficacy of CBZ.”
Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food: A Systematic Review
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