Possible Interaction: Carbamazepine and Lithium Carbonate

“Comparison and contrast of the biological effects of carbamazepine with classical treatment agents, such as lithium carbonate , tricyclic antidepressants, and neuroleptics may help elucidate mechanisms underlying the pathophysiology of the mood disorders.”

“In view of the fact that therapy of affective psychoses with the combination of lithium carbonate with carbamazepine has been becoming ever common, the question arises about the influence of carbamazepine on plasma lithium concentration.”

“The comparative analysis has shown a high normothymic activity of carbamazepine and lithium carbonate in the patients examined, with the preventive action of carbamazepine being more remarkable as regards the economic and clinical indicators.”

“Exacerbation of psoriasis was observed in a 28‐year‐old patient following the addition of lithium carbonate to a treatment regimen of carbamazepine and other drugs for ***manic‐depressive psychosis.”

“1 As the clinical use of carbamazepine increases, it is likely that it will be used in combination with a variety of psychotropic agents, including lithium carbonate , other antidepressants, and monoamine oxidase inhibitors.”

“There are many potential reasons for the lack of a continued response to carbamazepine in combination with lithium carbonate in their case.”

“A case is described of a 22-year-old woman with bipolar affective disorder who developed severe neurotoxic symptoms when treated with a combined regimen of lithium carbonate and carbamazepine in therapeutic doses.”

“Patients 1, 2 and 4 showed favorable antimanic responses to carbamazepine used in combination with lithium carbonate.”

“ Lithium carbonate and carbamazepine , two drugs of use in the prophylactic treatment of affective illness, appear to have differential effects on sensitization and kindling.”