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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carbamazepine and Homocysteine

Research Papers that Mention the Interaction

After 1 year of therapy, patients treated with VPA and CBZ showed a significant increase of the plasma concentrations of Hcy when compared to baseline data and controls values.
Epilepsy Research  •  2000  |  View Paper
Psychiatrists may find it advisable to control the levels of folate and homocysteine in adults and children who are taking carbamazepine and to measure homocysteine level in children taking valproic acid.
Tijdschrift voor psychiatrie  •  2018  |  View Paper
The atherogenic effect of increased serum homocysteine level is well established, and patients under carbamazepine monotherapy should be monitored for possible atherogenic effects.
Clinical laboratory  •  2016  |  View Paper
We found that mean serum folate level was statistically lower and mean Hcy level was higher in epileptic patients receiving CBZ or VPA when compared with those of controls'.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2008  |  View Paper
Additionally, the underlying mechanism for homocysteine increase seems to be a decrease of cofactor molecules in patients using carbamazepine and phenytoin (pyridoxal 5'-phosphate and folic acid, respectively).
Seizure  •  2006  |  View Paper
In the carbamazepine-treated group , significantly positive correlation was found between duration of treatment and homocysteine concentration (p < 0.01).
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society  •  2000  |  View Paper
After treatment with carbamazepine combined with vitamin B12 for patients with epilepsy, the Hcy level was significantly higher than that before treatment and that in the control group (P<0.01).
Experimental and therapeutic medicine  •  2018  |  View Paper
Conclusions According to the … this study, as carbamazepine and valproate sodium consumption can … elevated serum levels of homocysteine and decreased levels of folate and vitamin B12, and the atherogenic effect of increased serum homocysteine … is well established, the patients under these medications should be monitored for possible atherogenic effects.
Iranian Red Crescent medical journal  •  2013  |  View Paper