supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Carbamazepine
supplement:
Glutathione
Research Papers that Mention the Interaction
“During the treatment with VPA or CBZ , the erythrocyte GSHpX and GSH levels of epileptic children were significantly changed as compared to those of health control subjects.”
The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children.“In addition, chronic treatment with other mood stabilizing drugs lamotrigine and carbamazepine , but not antidepressants desipramine and fluoxetine, increased both glutathione levels and the expression of glutamate-cysteine ligase in SH-SY5Y cells.”
“Despite the lack of clear-cut underlying clinical and experimental findings in those patients in whom an inherited weakness of drug eliminating capacity is present, those conditions that may deteriorate glutathione balance, may increase the possibility of the emergence of toxic events during carbamazepine therapy.”
“In addition, the activities of glutathione increased (p = 0.0001) significantly in the CBZ + GSME-treated rats.”
Graded doses of grape seed methanol extract attenuated ataxic movement, cerebellocortical toxicity, and impairment following chronic carbamazepine treatment in male Wistar rats“After 42 days exposure, reduced glutathione level was significantly decreased in the fish exposed at 0.2mg/l CBZ , compared with the control.”
“A single high dose of CBZ (100 mg/kg) produced a large and significant decrease relative to control ( GSH level 3.82 +/- 0.64 vs 6.54 +/- 0.45 mumol GSH/g liver).”
“Ascorbate and glutathione also appear to have an important role as antioxidants in response to increased concentrations of carbamazepine.”
Antioxidative response of lettuce (Lactuca sativa) to carbamazepine-induced stress
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback