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Last Updated: a year ago

Possible Interaction: Carbamazepine and Glutathione

supplement:

Glutathione

Research Papers that Mention the Interaction

During the treatment with VPA or CBZ , the erythrocyte GSHpX and GSH levels of epileptic children were significantly changed as compared to those of health control subjects.
Pharmacological research  •  2000  |  View Paper
In addition, chronic treatment with other mood stabilizing drugs lamotrigine and carbamazepine , but not antidepressants desipramine and fluoxetine, increased both glutathione levels and the expression of glutamate-cysteine ligase in SH-SY5Y cells.
Neuroscience  •  2007  |  View Paper
Despite the lack of clear-cut underlying clinical and experimental findings in those patients in whom an inherited weakness of drug eliminating capacity is present, those conditions that may deteriorate glutathione balance, may increase the possibility of the emergence of toxic events during carbamazepine therapy.
Adverse drug reactions and toxicological reviews  •  2002  |  View Paper
In addition, the activities of glutathione increased (p = 0.0001) significantly in the CBZ + GSME-treated rats.
Epilepsy & Behavior  •  2021  |  View Paper
After 42 days exposure, reduced glutathione level was significantly decreased in the fish exposed at 0.2mg/l CBZ , compared with the control.
Chemico-biological interactions  •  2010  |  View Paper
A single high dose of CBZ (100 mg/kg) produced a large and significant decrease relative to control ( GSH level 3.82 +/- 0.64 vs 6.54 +/- 0.45 mumol GSH/g liver).
Drug metabolism and drug interactions  •  1998  |  View Paper
Ascorbate and glutathione also appear to have an important role as antioxidants in response to increased concentrations of carbamazepine.
Environmental Science and Pollution Research  •  2021  |  View Paper