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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbamazepine
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“Brain GABA levels were below normal in four of nine patients taking carbamazepine or phenytoin and one of five taking valproate.”
Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures“Gene expression analysis revealed that GABA and glutamate metabolic pathways in zebrafish larvae were altered following exposure to CBZ.”
“In cortical neuron recordings, the current induced by 1 microM GABA was enhanced by carbamazepine and phenytoin with EC50 values of 24.5 nM and 19.6 nM and maximal potentiations of 45.6% and 90%, respectively.”
“We report here that carbamazepine and phenytoin, two widely used antiepileptic drugs, potentiate gamma-aminobutyric acid (GABA)-induced Cl- currents in human embryonic kidney cells transiently expressing the alpha 1 beta 2 gamma 2 subtype of the GABAA receptor and in cultured rat cortical neurons.”
“ CBZ increased in a concentration dependent manner sub-maximal α1β2γ2 and α3β2γ2 GABA currents.”
Carbamazepine aggravates absence seizures in two dedicated mouse models.“Supratherapeutic doses of AZM, CBZ , PHT, TPM, and ZNS decreased extracellular levels of GABA , NE, DA, and 5-HT, without affecting Glu levels.”
“In vitro studies in Xenopus oocytes expressing recombinant GABAA receptors demonstrated that CBZ produced a dose-dependent potentiation of the GABA current at a physiological relevant concentration range (1–100 μM).”
“ Carbamazepine increased the GABA level but did not effect GAD and GABA-T activities.”
“All the three dibenzazepine carboxamide derivatives, BIA 2-093, CBZ and OXC inhibited in a concentration dependent manner (from 30 to 300 microM) the veratrine-induced release of glutamate, aspartate, GABA and dopamine.”
“The inhibitory effect of GABA was facilitated by concurrent application of desipramine, carbamazepine or diazepam at a concentration of 5 x 10(-5)-2 x 10(-4) M. The rank of order of facilitation is: desipramine > carbamazepine > diazepam.”
“These results suggest a GABA component to the mechanism(s) of action of CBZ: (a) CBZ reduces extracellular available GABA concentration, and (b) owing to the known inhibitory role of preoptic GABA in pituitary LH secretion, an increase of postsynaptic GABAergic transmission by CBZ itself could be inferred.”
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