Possible Interaction: Carbamazepine and Diosmin

“Furthermore, treatment with DSN significantly decreased the metabolite to parent ratios of Cmax and AUC, indicating the reduced metabolism of CBZ to CBZE.”

“On the other hand, treatment with DSN significantly decreased the Cmax and AUC of carbamazepine 10 , 11-epoxide (CBZE).”

“Therefore, we conclude that DSN has an inhibiting effect on the metabolism and disposition of CBZ.”

“Treatment with SN significantly enhanced the maximum plasma concentration (Cmax), area under the curve (AUC), half-life (t1/2) and significantly decreased the apparent oral clearance (CL/F) and elimination rate constant (Kel) of C BZ. ”

“Accordingly, caution should be taken when diosmin is used in combination with therapeutic drugs metabolized by CYP3A enzyme in addition to CBZ.”

“Epileptic patients with hemorrhoids and varicose veins may use diosmin along with carbamazepine (CBZ) therapy, which leads to pharmacokinetic interaction between diosmin and CBZ.”

“On the other hand, Cmax, AUC, and t1/2 of carbamazepine 10 , 11-epoxide (CBZE) were significantly (p < 0.05) decreased after diosmin pretreatment.”

“Pretreatment with diosmin significantly (p < 0.05) enhanced maximum plasma concentration (Cmax), area under the curve (AUC), and half life (t1/2), while significantly (p < 0.05) decreased elimination rate constant (kel) and apparent oral clearance (CL/F) of CBZ as compared to control rats.”

“The results suggest that diosmin pretreatment might have inhibited CYP3A-mediated metabolism of CBZ.”