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Last Updated: a year ago

Possible Interaction: Carbamazepine and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

Cocaine and lidocaine release corticotropin‐releasing hormone (CRH) in hypothalamic cell cultures, and this effect is also blocked by CBZ.
Summary: Carbamazepine (CBZ) blocks the development of local anesthetic seizures kindled by cocaine and lidocaine.
Epilepsia  •  1992  |  View Paper
BALB and C57 mice, but not SJL mice, chronically treated with dietary CBZ were less susceptible to a consulvant dose of cocaine than their corresponding dietary controls for at least 72 h after stopping CBZ administration.
In addition, there were genotype-specific lethal effects associated with the concurrent administration of CBZ and cocaine.
Brain Research  •  1992  |  View Paper
Our data suggest that carbamazepine is inhibiting mechanisms associated with local anesthetic kindling and only minimally affecting the psychomotor stimulant effects of cocaine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  •  1990  |  View Paper
At the highest carbamazepine dose in the high cocaine baseline group, carbamazepine reduced cocaine infusions by at least 50 percent and food intake by approximately 25 percent during the 8 days of treatment.
Pharmacology Biochemistry and Behavior  •  1990  |  View Paper