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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbamazepine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“… carbamazepine …), calcium (B = -0.262, p = 0.004), phosphorus (B = -0.241, p = 0.022), WBC (B = -0.288, p = <0.001), PLT (B = -0.236, …), NEU% (B = -0.289, p = <0.001), LYM% (B = -0.268, p = 0.001), D vitamini (B = -0.344, p = 0.006) levels.”
Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters.“Results Levels of vitamin D (standardized mean difference [SMD]: −0.62, 95% CI: −0.89 to −0.35) and calcium (SMD: −0.38, 95% CI: −0.67 to −0.09) were significantly lower in the CBZ group than controls.”
“ CBZ , PHT, and VPA, but not lamotrigine (LTG), are associated with lower levels of calcium.”
“Compounds such as carbamazepine , phenytoin, and probably valproate act by modifying ionic conductances, particularly sodium and calcium , in excitable membranes, thus limiting sustained high‐frequency neuronal discharges.”
“ Carbamazepine caused statistically significant, but clinically insubstantial, reductions in serum sodium and calcium , but not in the other electrolytes measured.”
“Four results were obtained: (1) The carbamazepine-alquine derivative 10-9 mM increased the perfusion pressure and vascular resistance in comparison with the …-6 mM blocked the effects exerted by the carbamazepine-alquine derivative 10-9-10--4 mM on left ventricular pressure, and (4) the carbamazepine-alquine … calcium …).”
[Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow].“ CBZ inhibited the rise in intracellular free Ca++ concentration ([Ca++]i) induced by NMDA and glycine in a rapid reversible and concentration-dependent manner.”
“Since some antidepressant drugs and the antiepileptic substance carbamazepine have calcium antagonistic properties, the interaction of BU and IPSA with carbamazepine and the organic calcium channel blocker verapamil was analyzed in the low Mg2+ induced model epilepsy which has been shown to be suppressed specifically by organic calcium antagonists.”
“These results suggest that CBZ blocks the slow sodium current, possibly via a decrease in intracellularly stored calcium ions.”
“ Carbamazepine , phenobarbital, diazepam and lidocaine also inhibit veratridine- and K-stimulated Ca uptake, but ethosuximide and valproic acid are ineffective.”
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