Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Carbachol and Tyrosine



Research Papers that Mention the Interaction

Carbachol also increased tyrosine phosphorylation of p38 MAP kinase.
The American journal of physiology  •  1997  |  View Paper
In this study, we show that in cells expressing ml mAChRs, the cholinergic agonist carbachol , induces a rapid and dose-dependent increase in tyrosine phosphorylation of cellular proteins which are different from those induced by PDGF.
Biochemical and biophysical research communications  •  1992  |  View Paper
CCh rapidly induced tyrosine phosphorylation of FAK in T84 cells.
Journal of cellular physiology  •  2005  |  View Paper
An investigation of tyrosine phosphorylation levels of the plasma membrane Ca2+-ATPase (PMCA) demonstrated that CCh stimulates an increase in tyrosine phosphorylation levels, which has been reported to inhibit Ca2+ pump activity, whereas in contrast, BK stimulates a reduction of PMCA tyrosine phosphorylation levels.
The Journal of Biological Chemistry  •  2003  |  View Paper
CCh (100 μm) stimulated tyrosine phosphorylation and association of the Ca2+-dependent tyrosine kinase, PYK-2, with the EGFR, which was inhibited by the Ca2+ chelator, BAPTA (20 μm).
CCh also induced tyrosine phosphorylation of p60 src and association of p60 src with both PYK-2 and the EGFR.
The Journal of Biological Chemistry  •  2000  |  View Paper
Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2.
Biochemical and biophysical research communications  •  1999  |  View Paper
That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120‐src substrate, which was inhibited by PP1.
Journal of neuroscience research  •  1999  |  View Paper
Carbachol concentration-dependently induced tyrosine phosphorylation of several proteins, including one of 42 kDa.
The Biochemical journal  •  1993  |  View Paper
Carbachol increased the phosphorylation of Pyk2 on tyrosine 402 and c-src on tyrosine 416 in a time-dependent manner.
Investigative ophthalmology & visual science  •  2006  |  View Paper
Carbachol also increased tyrosine phosphorylation of Pyk2, p60Src, and the epidermal growth factor receptor (EGFR).
American journal of physiology. Cell physiology  •  2003  |  View Paper
Show More