Possible Interaction: Carbachol and Tubocurarine

“Moreover, it shows that carbachol exerts an additional agonistic action on nicotinic cholinergic receptor of prostate cancer cells that can be blocked by tubocurarine.”

“In contrast, 1--10 nM carbamoylcholine produced diminished in vitro proliferation, an effect which was blocked by the nicotinic antagonists alpha-bungarotoxin and d-tubocurarine.”

“Application of a somewhat larger quantity of DTC (about 4 x 10-10 C) produces a transient 50 % inhibition of the acetylcholine (or carbachol ) potential.”

“The effect of carbachol was blocked by two nicotinic blockers, mecamylamine (10−6 M) and d-tubocurarine (10−6 M).”

“2) Carbachol increased the uptake of 86Rb+; this increase was inhibited by hexamethonium and d-tubocurarine.”

“ D-tubocurarine reduced the effect of carbamylcholine.”

“The paired-pulse facilitation of the synaptic potentials changed significantly under the action of carbamylcholine and d-tubocurarine.”

“ Carbachol , a non-specific cholinergic agonist, selectively induced phosphorylation of TH at serine 31 in darkness, an effect which was blocked by the nicotinic antagonist, d-tubocurarine.”

“The iontophoretic carbachol response is antagonized by alpha-bungarotoxin (EC50 = 0.19 microM), mecamylamine (EC50 = 0.32 microM), d-tubocurarine (EC50 = 9.5 microM), and bicuculline but not by decamethonium and scopolamine.”

“The uncoupling effects of carbachol and DMPP were blocked by the nicotinic antagonist D-tubocurarine and by the dopamine antagonist fluphenazine, indicating that carbachol uncoupled horizontal cells by stimulating dopamine release via nicotinic receptors.”

“ Tubocurarine produced a concentration-dependent reduction in the EMG responses, EPP amplitude, mean quantal content and carbachol sensitivity.”