Possible Interaction: Carbachol and Secretin

“When secretin was added to 1 mM carbachol , there was a slight increase in zymogen activation, but no change in the secretion of amylase or chymotrypsin.”

“Oxygen uptake increased further when carbamylcholine was superimposed on secretin.”

“ Secretin inhibited insulin secretion induced by carbachol and LIPNA, whereas VIP potentiated L-IPNA-induced insulin secretion and had no influence on the effect of carbachol.”

“Combination of secretin with carbachol or caerulein increased the amylase output to about 40%.”

“When secretin was combined with carbachol or caerulein, granule depletion, originally confined to small groups of neighbouring acini, spread to form large areas of degranulated cells, sometimes comprising a whole section of a lobule.”

“3 The physiological concentration of secretin (50 pm) had a relatively weak effect on IKs (160 % increase), which was significantly enhanced by transient co‐stimulation with carbachol (CCh) (10 μm).”

“Synergistic effects were found between carbachol and either secretin or vasoactive intestinal peptide in the regulation of DOPA (dihydroxyphenylalanine) synthesis.”

“In in vitro study, a combined administration of secretin and carbachol or cholecystokinin octapeptide (CCK-8) to the culture medium of chief cells potentiated pepsinogen secretion.”

“Stimulation of amylase release by increasing concentrations of carbamylcholine resulted in a dose-dependent recruitment of secreting acini as well as in a time-dependent enhancement in the response of individual acini.”

“In addition, BPP inhibited the potentiation of amylase secretion caused by the combination of carbachol plus secretin or vasoactive intestinal peptide.”

“A combination of carbachol and secretin (4.25 nmol kg-1) enhanced plasma glucagon levels to 1.22 +/- 0.07 ng ml-1.”