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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbachol
supplement:
Prolinedithiocarbamate
Research Papers that Mention the Interaction
“Either M3 cholinergic receptor antagonist (10(-5) mol/L atropine) or NF-kappaB inhibitor (10(-2) mol/L PDTC ) could obviously inhibit the activation of NF-kappaB and the chemokine MOB-1, MCP-1 mRNA expression induced by carbachol (P<0.05).”
Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells.“The addition of 10−2 mol/L PDTC resulted in a significant decrease of NF-κB activities in pancreatic acinar cells after treated with high concertrations of carbachol (10−3 mol/L) in vitro, but the intracelluar trypsinogen activity was not obviously inhibited (P>0.05).”
Relationship between carbachol hyperstimulation-induced pancreatic intracelluar trypsinogen and NF-κB activation in rats in vitro“The action of carbachol was inhibited by the intracellular Ca(++) chelator BAPTA-AM, the PKC inhibitor GF109203X, and the NF-kappaB inhibitor PDTC.”
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