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Last Updated: a year ago

Possible Interaction: Carbachol and Procaine

supplement:

Procaine

Research Papers that Mention the Interaction

Procaine (30 mM) blocked the carbachol (50 microM) contractions in bladders but not in taenia.
European journal of pharmacology  •  2007  |  View Paper
In the presence of procaine, carbachol was inhibited and only slightly reduced the Ca2+-deposits on the plasma membranes.
Cell and Tissue Research  •  2004  |  View Paper
2 Procaine inhibited the catecholamine secretion evoked by 500 μm carbachol (CCh) with an IC50 of 35 μm and the associated calcium influx (IC50 60 μm).
5 In agreement with the ion flux studies, procaine inhibited the inward current evoked by CCh.
British journal of pharmacology  •  1992  |  View Paper
The 22Na uptake due to carbachol was inhibited by atropine, procaine or CoCl2; the response to Substance P was inhibited by CoCl2 only.
The Journal of physiology  •  1979  |  View Paper
The local anaesthetics tetracaine and procaine inhibited both the transient and sustained phases of the responses to carbachol and phenylephrine; responses to Substance P and to the divalent cationophore, A23187, were largely refractory to this effect.
The Journal of physiology  •  1978  |  View Paper
Procaine inhibited the increase in O 2 consumption due to carbachol , but not that due to substance P. When both carbachol and substance P were presented to the tissues in series and in the absence of external Ca, the second agonist failed to produce a response.
Life sciences  •  1978  |  View Paper
Procaine (1.0 mM), however, blocked the response to carbachol but not substance P. These results support an hypothesis suggesting that Co++ blocks inward transport of Ca++ while procaine interferes with the transduction mechanism linking the muscarinic receptor to the Ca++ channel.
Molecular pharmacology  •  1978  |  View Paper
Procaine (27×10-5 g/ml; 1 mM) supPressed both the depolarization and the desensitization induced by Carb.
The Japanese journal of physiology  •  1973  |  View Paper