Possible Interaction: Carbachol and Potassium

“ CAR induced a potassium mediated outward current via activation of M2 muscarinic receptors in 43% of SubCD cells.”

“Both carbachol and adenosine similarly inhibited quantal release triggered by high potassium , ionomycin or sucrose.”

“Thus, carbachol stimulated the hydrolysis of PI to 146% and 386% of control levels at potassium concentrations of 5.8 and 18.2 mmol/l, respectively, in the rat hippocampus.”

“Ionomycin, α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate, or potassium depolarization, which increased [Ca2+]i but was ineffective on [3H]AA release, also potentiated the carbachol response.”

“At a dosage of 5 μg/kg body wt, carbamylcholine decreased net influx of potassium (15%) in the RES rat but was without effect on normal rat.”

“The calcium‐dependent potassium current, IAHP, and the voltage‐dependent potassium current, IM, were both reversibly blocked by the application of carbachol (5‐10 microM).”

“The reversal potentials in carbachol shifted in a positive direction when bathing potassium concentration was increased.”

“Strips precontracted by l-norepinephrine or by high potassium concentrations were slightly (4%) relaxed by 0.1 microM CCh , but further contracted by higher concentrations.”

“In contrast, carbachol hyperpolarized the resting membrane by 4.5 +/- 0.8 mV (n = 11) and increased resting potassium conductance more than 4-fold in saline-treated animals.”

“Intracerebroventricular (ICV) infusion of carbachol increased the rates of sodium excretion and clearance, potassium excretion and clearance, osmolal clearance and solute-free water reabsorption and increased the concentration of vasopressin in arterial plasma.”

“Sodium, potassium and osmolal clearances were increased after administration of carbachol.”