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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbachol
supplement:
Polypeptides
Research Papers that Mention the Interaction
“… PP … carbachol (12.3 ± 0.3 vs. 9.0 ± 0.3% total amylase release in control and PP treated, respectively), decreased the magnitude of the difference … amylase release in control and PP treated, respectively), and affected these changes without modifying the dose of carbachol producing half-maximal amylase release.”
Modulation of Pancreatic Exocrine Function in Rodents by Treatment with Pancreatic Polypeptide“Secretion of PP by SL and UP cultures in response to 5 μM carbachol and 2.8 mM glucose in a 2-h incubation was significantly greater, 2.2- (p < 0.002) and 3.9-fold (p < 0.002), respectively, than secretion by respective control cultures without carbachol.”
“Incubation of labelled synaptosomes with the cholinergic agonist carbachol resulted in a modest, but statistically significant, increase in the phosphorylation of the 45 K (B-50) and 82 K polypeptides.”
“In these intact cells, carbachol increased the phosphorylation of three polypeptides with Mr values of 21500, 24 000 and 29000.”
“The specific cholinergic ligand, carbachol , inhibited phosphorylation of these four polypeptides by 72% in the presence of 1mM Na+ and 100 mM K+.”
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