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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Carbachol
supplement:
Oleic Acid
Research Papers that Mention the Interaction
“Incubation of AML12 hepatocytes with 1 mM oleic acid resulted in lipid accumulation that was significantly reduced by co-treatment with a muscarinic agonist (pilocarpine or carbachol ), an effect blocked by atropine (a muscarinic antagonist).”
M3 Muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway.“Those … carbachol were repeated following a … min incubation with either oleic acid (10(-4) M) or palmitic acid (10(-4) M), demonstrating significant impairment of endothelium-dependent vasodilation with both [P<0.05, comparison of pD2 values (the negative log concentration of agonist required to effect a 50% response)].”
Non-esterified fatty acids impair endothelium-dependent vasodilation in rat mesenteric resistance vessels.“ Carbachol and ATP induced a rapid increase in the amount of [3H]phosphatidic acid in astroglial cells prelabelled with [3H]oleic acid.”
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