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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Finally, in PTX‐incubated INS1 cells, melatonin (100 nmol/L) increased carbachol (300 μmol/L)‐induced insulin release (up to 124% of insulin release).”
“Surprisingly, incubation of carbachol (300 μmol/L)‐stimulated cells with melatonin (100 nmol/L) inhibited insulin release (down to 75% of insulin release).”
Parallel signaling pathways of melatonin in the pancreatic β‐cell“Subsequent treatment of the cells with carbamylcholine (CCh), an agonist of mAChR, induced phase-dependent phase shifts of the melatonin rhythm in a manner very similar to the effect of light.”
“After precontraction with carbachol (10(-6) M) or serotonin (10(-7) M), melatonin caused a concentration dependent inhibitory action.”
“Thus, it is concluded that melatonin has an pharmacological inhibition effect on the contraction uterine provoked by carbachol , act as physiological antagonist.”
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