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Last Updated: a year ago

Possible Interaction: Carbachol and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

Finally, in PTX‐incubated INS1 cells, melatonin (100 nmol/L) increased carbachol (300 μmol/L)‐induced insulin release (up to 124% of insulin release).
Surprisingly, incubation of carbachol (300 μmol/L)‐stimulated cells with melatonin (100 nmol/L) inhibited insulin release (down to 75% of insulin release).
Journal of pineal research  •  2006  |  View Paper
Subsequent treatment of the cells with carbamylcholine (CCh), an agonist of mAChR, induced phase-dependent phase shifts of the melatonin rhythm in a manner very similar to the effect of light.
The Journal of Neuroscience  •  2002  |  View Paper
After precontraction with carbachol (10(-6) M) or serotonin (10(-7) M), melatonin caused a concentration dependent inhibitory action.
Canadian journal of physiology and pharmacology  •  2000  |  View Paper
Thus, it is concluded that melatonin has an pharmacological inhibition effect on the contraction uterine provoked by carbachol , act as physiological antagonist.
Ginecologia y obstetricia de Mexico  •  1993  |  View Paper