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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“While genistein inhibited extracellular Ca(2+) or Mn(2+) entry induced by CCK and carbachol , it did not affect intracellular Ca(2+) release and oscillations.”
Receptor-operated Ca2+ influx and its association with the Src family in secretagogue-stimulated pancreatic acini.“ Genistein also acted synergistically with the Ca(2+)- and protein kinase C-dependent acetylcholine analogue, carbachol , to stimulate Cl- secretion in T84 monolayers.”
“The contraction induced by carbachol (CCh) was significantly inhibited by pretreatment with selective Tyr kinase inhibitors ( genistein and ST638, n = 6, respectively), and a JNK inhibitor (SP600125, n = 6).”
Involvement of the Tyr Kinase/JNK Pathway in Carbachol-induced Bronchial Smooth Muscle Contraction in the Rat“The … of genistein was markedly attenuated not only after treatment … inhibitor of cAMP synthesis Sq 22536, carbachol or an inhibitor of specific protein kinase A H-89, but also after the inhibition of … reticulum Ca2+ mobilization by ruthenium red, ryanodine or the inhibitor of sarcoplasmic reticulum Ca2+-ATPase thapsigargin.”
“ Genistein concentration-dependently relaxed histamine (30 microM)-, carbachol (0.2 microM)-, KCl (30 mM)- and leukotriene D4 (10 nM)-induced precontractions and inhibited cumulative histamine- and carbachol-induced contractions in a non-competitive manner.”
“Calphostin C (a PKC inhibitor), U73122 (a PPI-PLC inhibitor) and genistein (a tyrosine kinase inhibitor) blocked the activation of PLD, of PLC and the phosphorylation of tyrosyl residues in response to carbachol and vanadate.”
“Treatment with … μM genistein (an inhibitor of tyrosine kinase), 25 μM LY‐294002 (a PI‐3 kinase blocker), 30 nM brefeldin‐A (a blocker of polypeptides …), 50 nM K‐252a (a Trk receptor inhibitor) and 20 μM fluorodeoxyuridine (an inhibitor of cell proliferation) totally inhibited the effect of carbamylcholine.”
“In contrast, genistein significantly enhanced the relaxation response to carbachol in pulmonary arteries from hypoxic rats, restoring it to the levels seen in normoxic rats.”
“ Carbachol contractions were partially suppressed by genistein (106 +/- 8% vs. 79 +/- 8%; P < 0.05) but unaffected by tyrphostin B46 (114 +/- 10% vs. 107 +/- 12%; P > 0.05).”
“In addition, genistein caused an inhibition of a basal K+ conductance and inhibited the Ca(2+)-dependent K+ conductance stimulated by carbachol.”
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