Possible Interaction: Carbachol and Gamma-Aminobutyric Acid

“Here we show that exposing OB slices to carbamylcholine (CCh), a hydrolysis-resistant analog of Ach, increases gamma-aminobutyric acid (GABA) release at dendrodendritic synapses onto the mitral cells.”

“ GABA also enhanced the response to carbachol in hippocampal and striatal slices and to ibotenic acid in hippocampal slices.”

“ Carbachol dose‐dependently enhanced the release of 3H‐GABA.”

“On the other hand, this hyperactivity elicited by the injection of carbachol was also reduced by the injection of GABA into the subpallidal area.”

“In … of carbachol , a muscarinic receptor agonist, resulted in … significant suppression of the release of [3H]GABA evoked by high potassium (50 mM) stimulation in a dose dependent manner, while noradrenaline, isoproterenol, dopamine, …-hydroxytryptamine, histamine and glutamic acid had no significant effect on the evoked release of [3H]GABA.”

“Similarly, carbachol (5 x 10(-4) M) enhanced by 9% the release of [3H]GABA.”

“In addition, in untreated neurons, baclofen had no acute effect, whereas GABA inhibited the effect of l‐glutamate and carbachol.”

“ gamma-Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.)”

“ GABA injection decreased the effects of the carbachol and atropine injection decreased the effects of the GABA on sodium and potassium excretion.”

“ GABA (0.019-1.25 mM) suppressed and both acetylcholine (1.25-80 microM) and carbachol (1.25-40 microM) increased spontaneous activity.”