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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carbachol and Fluorides

supplement:

Fluorides

Research Papers that Mention the Interaction

Fluoride enhanced basal production of 3H‐inositol phosphates in membranes prepared from brain cortical slices that had been prelabeled with [3H]inositol, but inhibited the stimulation elicited by carbachol in the presence of GTPγS. However in both cases fluoride depleted [3H]PtdIns4P content by 95%.
International Journal of Developmental Neuroscience  •  1999  |  View Paper
Consequently, under conditions where breakdown of polyphosphoinositides by … was dependent on PtdIns kinase activity, fluoride inhibited activation …[S] plus carbachol of phospholipase C. When conditions allowed direct breakdown of PtdIns and precluded PtdIns kinase activity, … effects of fluoride and GTP[S] plus carbachol on phospholipase C activity were additive.
The Biochemical journal  •  1990  |  View Paper