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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Carbachol
supplement:
Edetic Acid
Research Papers that Mention the Interaction
“However, when EDTA (1 mM) was added, the stimulating effect of carbachol alone or carbachol + K+ was almost completely prevented.”
Potassium ions potentiate the muscarinic receptor-stimulated phosphoinositide metabolism in cerebral cortex slices: A comparison of neonatal and adult rats“Furthermore, the inhibitory effect of carbachol was attenuated by the presence of 1 mM EDTA in media for pretreatment, suggesting that intracellular pathways activated by pancreatic secretagogues may be responsible for somatostatin receptor modulation.”
“When 1 mM EDTA was present in the pretreatment medium, the inhibitory effect of carbachol or CCK8 was partially abolished, suggesting that an intracellular process to modulate somatostatin binding is dependent on Ca2+.”
“Omission of calcium ions from the incubation medium and pre‐treatment of the slices with ethylenediaminetetraacetic acid (EDTA) caused a marked reduction in alkaline phosphatase secretion induced by carbamylcholine but had no effect on incorporation of P32 into phospholipids.”
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