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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Carbachol and Dehydroepiandrosterone

Research Papers that Mention the Interaction

DHEA also inhibited the carbachol induction of phosphoinositide generation, with a maximal inhibition at 0.1 nM DHEA.
Furthermore, DHEA inhibited insulin secretion induced by carbachol in INS-1 cells by 25%, and in human pancreatic islets by 53%.
Steroids  •  2006  |  View Paper
…,DHEA (0.1 microM) significantly diminished the desensitization … APP secretion in cells exposed to carbachol for 24 h. The effect of DHEA on APP processing is probably not related to up-regulation of m1AChR or increased m1AChR-activated phosphoinositide hydrolysis since these parameters did not change following DHEA treatment.
Annals of the New York Academy of Sciences  •  1995  |  View Paper