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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Carbachol
supplement:
Dehydroepiandrosterone
Research Papers that Mention the Interaction
“ DHEA also inhibited the carbachol induction of phosphoinositide generation, with a maximal inhibition at 0.1 nM DHEA.”
“Furthermore, DHEA inhibited insulin secretion induced by carbachol in INS-1 cells by 25%, and in human pancreatic islets by 53%.”
Dehydroepiandrosterone inhibits intracellular calcium release in β-cells by a plasma membrane-dependent mechanism“…,DHEA (0.1 microM) significantly diminished the desensitization … APP secretion in cells exposed to carbachol for 24 h. The effect of DHEA on APP processing is probably not related to up-regulation of m1AChR or increased m1AChR-activated phosphoinositide hydrolysis since these parameters did not change following DHEA treatment.”
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