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Last Updated: a year ago

Possible Interaction: Carbachol and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

Cocaine inhibits the receptor noncompetitively, with an apparent KI of 84 and 26 microM at high and low carbamoylcholine concentrations , at which concentrations the receptor is mainly in the open- or closed-channel form, respectively.
Biochemistry  •  2004  |  View Paper
Cocaine (30 μmol/l) had no effect upon spontaneous 3H-efflux measured over 60 min, but reduced that evoked over the same period by carbachol (EC50), veratridine (EC50) and by ouabain (100 gmol/l).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
i) The apparent cocaine dissociation constant of the closed-channel receptor form is approximately 50 microM. High carbamoylcholine concentration and, therefore, increased concentrations of the open-channel receptor form, decrease receptor affinity for cocaine approximately 6-fold. (
Proceedings of the National Academy of Sciences of the United States of America  •  1995  |  View Paper
The sensitivity of the preparation to acetylcholine but not methacholine and carbachol was increased by cocaine.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1978  |  View Paper