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Last Updated: 4 months ago

Possible Interaction: Carbachol and Choline

supplement:

Choline

Research Papers that Mention the Interaction

Both drugs exerted consistent dose-related effects, choline being significantly less potent than carbachol.
European Journal of Clinical Pharmacology  •  1983  |  View Paper
In the fast application experiments, the peak current amplitude was reduced and the current rise time increased when choline was co-applied with carbachol.
The presence of choline resulted in inhibition of currents elicited by carbachol.
The Journal of physiology  •  2005  |  View Paper
On the other hand, the incorporation of [14C] choline into lipids was diminished by carbachol in the cell line expressing the M3 receptor subtype and unchanged in the other cell lines.
Brain Research Bulletin  •  1997  |  View Paper
Choline uptake was significantly decreased by carbachol but unaffected by atropine and d-tubocurarine.
Comparative biochemistry and physiology. Part A, Physiology  •  1995  |  View Paper
Treatment of 1321N1 cells with carbachol results in increases in radiolabeled choline , phosphatidic acid (PA) and phosphatidylethanol (PEt), metabolites that are products of phospholipase D (PLD) action on PC.
The Journal of biological chemistry  •  1990  |  View Paper
Carbachol (10 microM) rapidly enhanced the choline efflux by a muscarinic mechanism, that was independent of mepacrine, an inhibitor of phospholipase A2, as well as of extracellular Ca2+; the maximum acceleration was reached within 2 min.
Biochemical pharmacology  •  1988  |  View Paper
At high concentrations, however, choline antagonized the stimulatory effect of acetylcholine and carbachol , suggesting that it might act as a partial agonist at this subtype of muscarine receptors, similar to what has been observed with oxotremorine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1986  |  View Paper
This effect and the increase of choline efflux evoked by forskolin were blocked by 2×10−7 mol/l carbachol.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1986  |  View Paper