Possible Interaction: Carbachol and Choline

“In the fast application experiments, the peak current amplitude was reduced and the current rise time increased when choline was co‐applied with carbachol.”

“The presence of choline resulted in inhibition of currents elicited by carbachol.”

“Both drugs exerted consistent dose-related effects, choline being significantly less potent than carbachol.”

“At high concentrations, however, choline antagonized the stimulatory effect of acetylcholine and carbachol , suggesting that it might act as a partial agonist at this subtype of muscarine receptors, similar to what has been observed with oxotremorine.”

“On the other hand, the incorporation of [14C] choline into lipids was diminished by carbachol in the cell line expressing the M3 receptor subtype and unchanged in the other cell lines.”

“ Choline uptake was significantly decreased by carbachol but unaffected by atropine and d-tubocurarine.”

“Acetylcholine … carbachol produced inhibitory effects on the heart performance at 1.0 x 10(-11) M. Choline also exhibited inhibitory effects at a higher concentration, but atropine, curare, pilocarpine and hexamethonium bromide (all at 1.0 x 10(-4) M) exerted no significant effects on the spontaneous cardiac activities.”

“ Carbachol (10 microM) rapidly enhanced the choline efflux by a muscarinic mechanism, that was independent of mepacrine, an inhibitor of phospholipase A2, as well as of extracellular Ca2+; the maximum acceleration was reached within 2 min.”