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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Carbachol
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Chronic application of the mAchR agonist, carbachol (Cch), induces Arc transcription via ERK signaling and release of calcium from IP3-sensitive stores.”
Balancing Arc Synthesis, mRNA Decay, and Proteasomal Degradation“Chelation of calcium also inhibited MAPK activation by carbachol.”
“Han et al.20 reported that the muscarinic receptor agonist carbachol inhibited the Ca current stimulated by isoproterenol in myocytes from wild-type mice, but not in myocytes isolated from NOS3-KO mice.”
“Taken together, these results suggest that carbachol and guanine nucleotides regulate the activation of a cation channel that conducts calcium.”
“ Carbachol stimulated a transient followed by a sustained increase in intracellular calcium.”
“The Ca2+ antagonist , nifedipine, inhibited the elevation in [Ca2+]i induced by 1-10 microM carbachol (CCh), but had no inhibitory effect on that induced by 30 and 100 microM CCh.”
“In the human submandibular ductal cell line (HSG) thapsigargin and carbachol stimulated Ca2+ release from the internal Ca2+ pool , resulting in the activation of capacitatively regulated Ca2+ entry (CRCE).”
“In addition, if Ca2+ is released from a caged Ca2+ compound after a UV pulse, the resulting Ca2+ peak is much larger in the presence of CCh than in its absence.”
“OBJECTIVE We hypothesized that the release of calcium from intracellular stores contributes to the contractions produced by the agonists oxytocin, carbachol , and prostaglandin F(2 )(alpha ) in human myometrium.”
“ Carbachol increased intracellular calcium in a dose-dependent manner; as did oxotremorine-M, aceclidine, and pilocarpine.”
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