Possible Interaction: Captopril and Serum Albumin, Human

“The pH of the buffer solution and captopril– HSA interaction may play more important roles in transforming the secondary structure of HSA from α-helix to β-sheet in the corresponding captopril–HSA mixture than UV-B exposure.”

“There was little disulfide formation in the captopril–HSA mixture even with long-term UV-B exposure, but captopril might interact with HSA to change the protein secondary structure of HSA whether there was UV-B irradiation or not.”

“Thus, protein binding between HSA and captopril or captopril/ethanol seems to play an important role in protein secondary structure.”

“These data suggest that CPT is bound in the region of inter‐domain connections within the IIA structural domain of HSA and it induces relative movement of the protein structural domains.”