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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“During combined Captopril treatments (also with a diuretic) two patients had so severe hypokalaemia that they needed potassium substitution or administration of a potassium-saving diuretic.”
Combined captopril treatment in severe and moderately severe hypertension resistant to therapy.“ Captopril also suppressed the augmentation of P450c18 mRNA observed with potassium supplementation but had no effect on P450scc mRNA levels.”
In vivo regulation of gene expression of enzymes controlling aldosterone synthesis in rat adrenal“Finally, captopril inhibited potassium induction of aldosterone synthase P-450 mRNA levels despite the presence of low plasma renin activity in the potassium-treated rats.”
“It … that captopril pretreatment significantly reduced the magnitude of … secretory response to increments in potassium of 0.5 to 6.0 mM, from a baseline potassium concentration of 3.5 mM. Responses … the lowest increment in potassium, 0.5 and 1.0 mM, were virtually abolished by captopril treatment.”
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