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Last Updated: a year ago

Possible Interaction: Captopril and Melatonin



Research Papers that Mention the Interaction

MT not only partially regulated oxidative stress via AKT/FOXO signaling, but also reduced apoptosis caused by CP by inhibiting the Bax/caspase-3 pathway.
Our results indicated that MT could prevent acute kidney injury induced by CP in rats, presumably through upregulating the expression of Klotho, resulting in elevated anti-oxidant and anti-apoptotic properties.
…,MT treatment protected kidney tissue against oxidative damages and … the expression level of Klotho decreased by CP treatment, resulting in reduced phosphorylation of protein kinase B (AKT) and forkhead box O (FOXO) as … as reduced expression levels of B-cell lymphoma 2-associated X protein (Bax) and caspase-3.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2019  |  View Paper
Treatment with melatonin significantly mitigates lipid peroxidation, superoxide dismutase, and catalase activity and the level of reduced glutathione content abnormality induced by CP in mice testis.
Human & experimental toxicology  •  2014  |  View Paper
Administration of 20 mg/kg of melatonin led to marked proliferation and hypercellularity of immature myeloid elements after mice were treated with CP , as well as mitigated bone marrow suppression induced by CP.
RESULTS Treatment with me atonin si gnificantly reduced the number of MnPCEs induced by CP at all doses (p < 0.0001).
European review for medical and pharmacological sciences  •  2014  |  View Paper
These findings suggest that compounds 4a, 8 and melatonin were able to reduce the mutagenicity effect of CP in male mice.
European journal of medicinal chemistry  •  2008  |  View Paper
Treatment with CP plus melatonin provided significant amelioration of oxidative stress parameters.
Journal of pineal research  •  2006  |  View Paper
It is concluded that administration of CP imposes a severe oxidative stress to renal tissue and melatonin confers protection against the oxidative damage associated with CP.
Journal of pineal research  •  2001  |  View Paper
Melatonin did not appear mutagenic in either of the tests and significantly reduced … of ChA (%) from 16.9 +/- 1.6 (NMU), 13.7 +/- 3.5 ( CP ) and 8.7 +/- 0.3 (DMH) to 4.5 +/- 0.6, 4.… +/- 0.9 and 5.6 +/- 0.2, respectively, (p < 0.05).
Similarly, SHA frequency (%) under the melatonin influence was reduced from 18.6 +/- 0.4 (NMU), 17.7 +/- 0.4 ( CP ) and 10.0 +/- 0.5 (DVH) to 9.9 +/- 0.5, 6.1 +/- 0.3 and 7.5 +/- 0.2, respectively, (p < 0.05).
Voprosy onkologii  •  1997  |  View Paper