Possible Interaction: Captopril and Melatonin

“ MT not only partially regulated oxidative stress via AKT/FOXO signaling, but also reduced apoptosis caused by CP by inhibiting the Bax/caspase-3 pathway.”

“Our results indicated that MT could prevent acute kidney injury induced by CP in rats, presumably through upregulating the expression of Klotho, resulting in elevated anti-oxidant and anti-apoptotic properties.”

“…,MT treatment protected kidney tissue against oxidative damages and … the expression level of Klotho decreased by CP treatment, resulting in reduced phosphorylation of protein kinase B (AKT) and forkhead box O (FOXO) as … as reduced expression levels of B-cell lymphoma 2-associated X protein (Bax) and caspase-3.”

“Treatment with melatonin significantly mitigates lipid peroxidation, superoxide dismutase, and catalase activity and the level of reduced glutathione content abnormality induced by CP in mice testis.”

“Administration of 20 mg/kg of melatonin led to marked proliferation and hypercellularity of immature myeloid elements after mice were treated with CP , as well as mitigated bone marrow suppression induced by CP.”

“RESULTS Treatment with me atonin si gnificantly reduced the number of MnPCEs induced by CP at all doses (p < 0.0001).”

“These findings suggest that compounds 4a, 8 and melatonin were able to reduce the mutagenicity effect of CP in male mice.”

“Treatment with CP plus melatonin provided significant amelioration of oxidative stress parameters.”

“It is concluded that administration of CP imposes a severe oxidative stress to renal tissue and melatonin confers protection against the oxidative damage associated with CP.”

“ Melatonin did not appear mutagenic in either of the tests and significantly reduced … of ChA (%) from 16.9 +/- 1.6 (NMU), 13.7 +/- 3.5 ( CP ) and 8.7 +/- 0.3 (DMH) to 4.5 +/- 0.6, 4.… +/- 0.9 and 5.6 +/- 0.2, respectively, (p < 0.05).”

“Similarly, SHA frequency (%) under the melatonin influence was reduced from 18.6 +/- 0.4 (NMU), 17.7 +/- 0.4 ( CP ) and 10.0 +/- 0.5 (DVH) to 9.9 +/- 0.5, 6.1 +/- 0.3 and 7.5 +/- 0.2, respectively, (p < 0.05).”