Possible Interaction: Captopril and Iron, Dietary

“There was a statistically insignificant increase in AUC for total plasma captopril of 43% (1312 ng ml(-1) h, 95% CI -827-3451 ng ml(-1) h P = 0.27) when captopril was ingested with iron.”

“Furthermore, in contrast to our expectation, CP was shown to promote significantly iron uptake in not only iron-sufficient but also iron-deficient cells.”

“The total iron uptake by BT325 cells in CP treatment groups (25, 75, 150, 300 µg/ml) was significantly higher than that in the control (no CP addition) (all P<0.01).”

“The Fe3+ chelating agents deferoxamine (DFO), …-dimethyl-3-hydroxypyrid-4-one CP 020) and 1,2-diethyl-3-hydroxypyrid-4-one (CP … or diminished the increase in NTBI transport when present during Fe loading and reversed the stimulation in pre-loaded … relation to their abilities to decrease intracellular iron.”

“However, the reduction of angiotensin convertase activity induced by captopril administration resulted in a drop of plasma iron concentration, observed already within 1-2 hours after administration of the inhibitor, and especially within two days post partum.”

“Hence, captopril can act as prooxidant in the presence of iron or copper.”

“In an iron(III)/H2O2/ascorbate oxidant system, captopril enhanced deoxyribose oxidation only when it was pre-mixed with iron , whereas it did not influence sugar degradation when not pre-mixed with the metal or when ascorbate was omitted.”