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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Captopril and Hydroxyproline



Research Papers that Mention the Interaction

Oral administration of captopril (daily dose, 40 mg/kg) for 7 days in the rat resulted in increased urinary excretion of peptide-bound 4-hydroxy-L-proline compared to controls, indicating in vivo inhibition of tissue prolidases by captopril.
Biochemical pharmacology  •  1985  |  View Paper
Only captopril reduced LVH development in L24, whereas captopril and melatonin reduced left ventricular hydroxyproline concentrations in soluble and insoluble collagen, respectively.
Journal of hypertension  •  2010  |  View Paper
Furthermore, captopril partially reversed alterations in hydroxyproline concentration in soluble and insoluble collagenous fractions of the LV.
Journal of biomedical science  •  2005  |  View Paper
Results: In chronic colitis, captopril significantly reduced the score of macroscopic and histologic lesions, as well as the colonic tissue levels of collagen &agr;1, hydroxyproline , ANG II and TGF-β1 proteins, and TGF-β1 mRNA.
Inflammatory bowel diseases  •  2004  |  View Paper
RESULTS Ca topril tr eatment significantly reduced hep atic hydroxyproline le vels, mean fibrosis score, steady state messenger RNA levels of TGF-beta1 and procollagen alpha1(I), and matrix metalloproteinase 2 and 9 activity.
Gastroenterology  •  2001  |  View Paper
Moreover, captopril injection prevented the increase of hydroxypro-line content as an index of lung fibrosis.
Human & experimental toxicology  •  2001  |  View Paper
Lavage fluid hydroxyproline content was higher in CP rats when compared with controls.
Biochemical pharmacology  •  1998  |  View Paper
The concentration of hydroxyproline in ICP was significantly decreased by simultaneous captopril treatment.
Journal of molecular and cellular cardiology  •  1997  |  View Paper
At a dose of 50 mg/kg/d, captopril reduced the slope of the radiation dose response curve for lung HP content by a factor of 1.7, and completely prevented the increase in HP concentration.
Captopril produced a drug dose-dependent suppression in this radiation-induced HP accumulation.
International journal of radiation oncology, biology, physics  •  1990  |  View Paper