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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Captopril
supplement:
Hydroxyproline
Research Papers that Mention the Interaction
“Oral administration of captopril (daily dose, 40 mg/kg) for 7 days in the rat resulted in increased urinary excretion of peptide-bound 4-hydroxy-L-proline compared to controls, indicating in vivo inhibition of tissue prolidases by captopril.”
Inhibition of rat and human prolidases by captopril.“Only captopril reduced LVH development in L24, whereas captopril and melatonin reduced left ventricular hydroxyproline concentrations in soluble and insoluble collagen, respectively.”
Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril“Furthermore, captopril partially reversed alterations in hydroxyproline concentration in soluble and insoluble collagenous fractions of the LV.”
“Results: In chronic colitis, captopril significantly reduced the score of macroscopic and histologic lesions, as well as the colonic tissue levels of collagen &agr;1, hydroxyproline , ANG II and TGF-β1 proteins, and TGF-β1 mRNA.”
“RESULTS Ca topril tr eatment significantly reduced hep atic hydroxyproline le vels, mean fibrosis score, steady state messenger RNA levels of TGF-beta1 and procollagen alpha1(I), and matrix metalloproteinase 2 and 9 activity.”
“Moreover, captopril injection prevented the increase of hydroxypro-line content as an index of lung fibrosis.”
“Lavage fluid hydroxyproline content was higher in CP rats when compared with controls.”
“The concentration of hydroxyproline in ICP was significantly decreased by simultaneous captopril treatment.”
“At a dose of 50 mg/kg/d, captopril reduced the slope of the radiation dose response curve for lung HP content by a factor of 1.7, and completely prevented the increase in HP concentration.”
“ Captopril produced a drug dose-dependent suppression in this radiation-induced HP accumulation.”
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