Possible Interaction: Captopril and Homocysteine

“Mesna, captopril , and NAC caused a concentration-dependent increase in free Hcy.”

“Three-hundred micromolar mesna and captopril had a greater effect than equimolar NAC, increasing free Hcy by 33.9 +/- 5.0% and 32.0 +/- 2.6%, respectively compared to 22.3 +/- 2.4% for NAC, p < 0.001.”

“These results suggest that chronic captopril treatment reduces endogenous inhibitor of NOS in rats with homocysteine injection , which may contribute to the beneficial effect of captopril on homocysteine-induced endothelial dysfunction in vivo, and may be secondary to the antioxidative action of captopril.”

“Pre-incubation of aortic rings with captopril (3 ∼ 30 &mgr;mol/L) for 15 min and co-incubation of aortic rings with homocysteine (1 mmol/L) for another 30 min attenuated the inhibition of homocysteine in a dose-dependent manner.”

“These results suggest that captopril can prevent the inhibition of endothelium-dependent relaxation induced by homocysteine in isolated rat aorta, which may be related to scavenging oxygen free radicals and enhancing NO production.”

“This study was designed to investigate the effects of captopril , an angiotensin-converting enzyme inhibitor, on inhibition of endothelium-dependent relaxation induced by homocysteine in isolated rat aorta.”

“ CP , a reported blocker of amino acid uptake, strongly enhanced L-HCA responses whereas responses to the other amino acids remained little affected.”