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Last Updated: a year ago

Possible Interaction: Captopril and Glutathione



Research Papers that Mention the Interaction

In the kidneys, CP significantly increased renal injury molecule-1, interleukin-6 (IL-6), tumor necrosis factor α (TNFα) and glutathione concentrations, and caused renal tubular necrosis, and DNA injury assessed by Comet assay.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology  •  2019  |  View Paper
Interestingly, the simultaneous application of both acidic pH and GSH triggers promoted significantly the cleavage and release of CPT compared to the exertion of single trigger.
Bioconjugate chemistry  •  2018  |  View Paper
Thiol-containing drugs such as captopril and 6-mercaptopurine loaded within DEGNPs showed an "Off-On" release behavior in the presence of thiol-reducing agents such as glutathione and dithiothreitol.
Journal of the American Chemical Society  •  2013  |  View Paper
Intracellular iron levels may also be decreased through pharmacologic chelating agents, while antioxidants such as N-acetylcysteine, glutamine (glutathione precursor) and captopril have been shown to replenish glutathione redox potential and scavenge free radicals.
Bone Marrow Transplantation  •  2004  |  View Paper
Incubation of the cells with CP (2 mM and 10 mM) drastically attenuated the GSH and cysteine depletion caused by toxic concentrations of paracetamol (1 mM and 5 mM).
Acta biochimica Polonica  •  1997  |  View Paper
After captopril (30, 60 min) the glutathione and GSHPx increased compared with the pretreatment values.
Israel journal of medical sciences  •  1990  |  View Paper
CP increased the production of reactive oxygen species and nitric oxide, and lowered glutathione content, glutathione peroxidase and glutathione reductase activities in kidney.
Amino Acids  •  2020  |  View Paper
Biochemical analyses showed that CP caused significant elevation of malondialdehyde (MDA), reduction of total glutathione (GSH), and increment of proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) level, which were measured in bladder homogenates.
Supportive Care in Cancer  •  2019  |  View Paper
CAP group also showed a significant increase in GSH concentration with amelioration of histological changes of AP as well as MP group.
Digestive Diseases and Sciences  •  2018  |  View Paper
CP treatment triggered a significant increase in membrane lipid peroxidation (LPO) levels, protein carbonyl (PC) contents, and a decrease in reduced glutathione ( GSH ) and non‑protein thiol (NP‑SH) levels.
Molecular medicine reports  •  2017  |  View Paper
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