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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Captopril
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“[3H]d-ASP and [3H]GABA release were inhibited to different degrees by the synthetic cannabinoids WIN 55,212-2; CP 55,940, and arachidonyl-2′-chloroethylamide/N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (ACEA), as well as by the endocannabinoids, anandamide (AEA), and 2-arachidonoylglycerol (2-AG).”
Inhibition by Anandamide and Synthetic Cannabimimetics of the Release of [3H]d-Aspartate and [3H]GABA from Synaptosomes Isolated from the Rat Hippocampus“Administration of CP 93129 at 80 microM into the VTA also significantly decreased extracellular GABA concentrations in this region.”
“On the contrary, pretreatment with ip captopril was less effective in attenuating the depressor effect of GABA.”
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