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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Captopril
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ Captopril increased PRA by 63% (P less than .05) and decreased plasma epinephrine by 42% (P less than .01) and norepinephrine by 35% (P less than .01).”
Plasma renin activity and norepinephrine as predictors for antihypertensive effects of nifedipine and captopril.“… captopril produced a significant increase in plasma aldosterone (79 +/- 8 vs. 60 +/- 6 … +/- 52 vs. 265 +/- 29 nmol/l, p less than 0.01), adrenaline (119 +/- 21 vs. 76 +/- 10 pg/ml, p less than 0.05), …/ml, p less than 0.05) compared with time-matched placebo data.”
“ Captopril inhibited the auto-oxidation of epinephrine to adrenochrome at pH 10.2 where this auto-oxidation is superoxide-dependent, and at pH 7.8 where it is superoxide-independent and superoxide dismutase insensitive.”
“Heart rate and plasma concentration of adrenaline increased above pre-captopril levels.”
“Pretreatment with captopril (10(-4) M) significantly reduced [Asn1, Val5, Asn9]ANG I-elicited Epi and NE release and decreased basal catecholamine release.”
Angiotensins stimulate catecholamine release from the chromaffin tissue of the rainbow trout.“ Captopril increased adrenal flow by 20 percent, an effect subsequently reversed by meclofenamate.”
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