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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Captopril and Epinephrine

supplement:

Epinephrine

Research Papers that Mention the Interaction

Captopril increased PRA by 63% (P less than .05) and decreased plasma epinephrine by 42% (P less than .01) and norepinephrine by 35% (P less than .01).
American journal of hypertension  •  1991  |  View Paper
captopril produced a significant increase in plasma aldosterone (79 +/- 8 vs. 60 +/- 6 … +/- 52 vs. 265 +/- 29 nmol/l, p less than 0.01), adrenaline (119 +/- 21 vs. 76 +/- 10 pg/ml, p less than 0.05), …/ml, p less than 0.05) compared with time-matched placebo data.
Hypertension  •  1989  |  View Paper
Captopril inhibited the auto-oxidation of epinephrine to adrenochrome at pH 10.2 where this auto-oxidation is superoxide-dependent, and at pH 7.8 where it is superoxide-independent and superoxide dismutase insensitive.
The American journal of cardiology  •  1990  |  View Paper
Heart rate and plasma concentration of adrenaline increased above pre-captopril levels.
Scandinavian journal of clinical and laboratory investigation  •  1986  |  View Paper
Pretreatment with captopril (10(-4) M) significantly reduced [Asn1, Val5, Asn9]ANG I-elicited Epi and NE release and decreased basal catecholamine release.
The American journal of physiology  •  1997  |  View Paper
Captopril increased adrenal flow by 20 percent, an effect subsequently reversed by meclofenamate.
The American journal of cardiology  •  1982  |  View Paper