Possible Interaction: Captopril and Copper

“Penicillamine, another agent associated with neutropenia and, like captopril , having a reactive thiol group, also inhibited colony formation in the presence of copper.”

“We have reported previously that Cp is regulated by cellular iron status, but the process of the regulation of Cp by copper still remains a subject for investigation.”

“Whereas, in a copper-free medium, PDTC failed to activate either AP-1 or Cp synthesis, supplementation of copper could reverse AP-1 activation and Cp synthesis.”

“The CP digestibility was higher in both CU and CUF.”

“The mRNA expression of CPT Iα1a, CPT Iα1b and CPT Iα2a in the liver, and CPT Iα1a, CPT Iα1b and CPT Iβ in the muscle as well as CPT Iα1a in the heart were up-regulated by Cu exposure.”

“To our knowledge, for the first time, the present study provided evidence that waterborne Cu exposure could influence carnitine composition, CPT I kinetics and mRNA levels of four CPT I isoforms in yellow catfish, which served to increase our understanding of the mechanisms underlying lipid catabolism during Cu exposure.”

“These observations support the possibility that liver copper loading increases metallation of the Cp protein , leading to increased production of the holo enzyme.”

“The moisture (%) of the 9th to 11th rib sections increased (linear; P = 0.03), ether extract (%) decreased (linear; P = 0.02), and CP and ash (%) tended to increase (linear; P = 0.09 and 0.06, respectively) as Cu supplementation increased.”

“In this work … presence of copper ions the … by CAP (molar ratio CAP:CuSO4 4:1) was two orders of magnitude higher (approximately 1.5 x 10(5) M-1s-…) than the literature value for superoxide scavenging by CAP alone (< 10(3) M-1s-1 at pH 7.4).”

“Hence, captopril can act as prooxidant in the presence of iron or copper.”