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Last Updated: a year ago

Possible Interaction: Captopril and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

Cocaine treatment resulted in increased phosphorylation of presynaptic proteins, rabphilin 3A and synapsin 1, and significantly attenuated CP 93129‐induced decrease in rabphilin 3A and synapsin 1 phosphorylation.
Journal of neurochemistry  •  2013  |  View Paper
The 5-HT(…) receptor agonist CP 94253 (2.5 or 5 mg/kg) … with a subthreshold priming dose of cocaine (2.5 mg/kg) potentiated reinstatement of the drug seeking-behavior, but inhibited cocaine seeking … by a submaximal dose (10 mg/kg) of cocaine or the cocaine-associated cue.
Pharmacological reports : PR  •  2008  |  View Paper
The inhibitory effects of CP 94253 (5 mg/kg) on the cocaine (0.125 or 0.25 mg/kg/injection) self-administration were blocked by SB 216641 (7.5 mg/kg).
…,CP 94253 (2.5-7.5 mg/kg) attenuated the cocaine (0.5 mg/kg/injection)-maintained responding … mg/kg, while its doses of 2.5-5 mg/kg potently reduced the self-administration of cocaine (0.125-0.25 mg/kg/injection), … increasing the unit dose of cocaine.
European journal of pharmacology  •  2007  |  View Paper
CP 154,526 in doses of 5, 10 and 20 mg/kg, which did not affect basal locomotor activity, dose-dependently reduced the hyperactivation evoked by cocaine.
Neuropeptides  •  2005  |  View Paper
The A1 and A2A receptor antagonists CPT and MSX-3) both produced high levels of drug-lever selection when substituted for either methamphetamine or cocaine and significantly shifted dose-response curves of both psychostimulants to the left.
Journal of Pharmacology and Experimental Therapeutics  •  2003  |  View Paper
When injected into the accumbens shell (but not the core) before cocaine, CP 93129 (0.1-10 microg/side) enhanced the locomotor response to cocaine ; the maximum effect being observed after 10 microg/side of the agonist.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2002  |  View Paper
In animals treated repeatedly with the psychostimulant, the behavioral response to a challenge dose of cocaine was dose-dependently increased when that drug was combined with CP 94,253, but not with GR 127935 + CP 94,253.
When rats were treated repeatedly with cocaine , a challenge dose of CP 94,253 produced an about threefold increase in the locomotor effect compared to the animals treated likewise with saline (Experiment 3).
Behavioural pharmacology  •  2001  |  View Paper
Finally, when CP 55,940 (50 microg/kg) was co-administered with cocaine , it significantly reduced the locomotor hyperactivity produced by the drug but did not block the development of behavioral sensitization.
European journal of pharmacology  •  1998  |  View Paper
Cocaine resulted in prolongation of an index of end-diastolic isovolumic relaxation time (τ) from a baseline of 34 milliseconds to 56 milliseconds … 15 minutes after cocaine administration in the control group and from a baseline of 35 milliseconds to 49 milliseconds in the captopril group (P<0.05).
Coronary artery disease  •  1993  |  View Paper