Possible Interaction: Captopril and Cocaine

“ Cocaine treatment resulted in increased phosphorylation of presynaptic proteins, rabphilin 3A and synapsin 1, and significantly attenuated CP 93129‐induced decrease in rabphilin 3A and synapsin 1 phosphorylation.”

“The 5-HT(…) receptor agonist CP 94253 (2.5 or 5 mg/kg) … with a subthreshold priming dose of cocaine (2.5 mg/kg) potentiated reinstatement of the drug seeking-behavior, but inhibited cocaine seeking … by a submaximal dose (10 mg/kg) of cocaine or the cocaine-associated cue.”

“The inhibitory effects of CP 94253 (5 mg/kg) on the cocaine (0.125 or 0.25 mg/kg/injection) self-administration were blocked by SB 216641 (7.5 mg/kg).”

“…,CP 94253 (2.5-7.5 mg/kg) attenuated the cocaine (0.5 mg/kg/injection)-maintained responding … mg/kg, while its doses of 2.5-5 mg/kg potently reduced the self-administration of cocaine (0.125-0.25 mg/kg/injection), … increasing the unit dose of cocaine.”

“ CP 154,526 in doses of 5, 10 and 20 mg/kg, which did not affect basal locomotor activity, dose-dependently reduced the hyperactivation evoked by cocaine.”

“The A1 and A2A receptor antagonists CPT and MSX-3) both produced high levels of drug-lever selection when substituted for either methamphetamine or cocaine and significantly shifted dose-response curves of both psychostimulants to the left.”

“When injected into the accumbens shell (but not the core) before cocaine, CP 93129 (0.1-10 microg/side) enhanced the locomotor response to cocaine ; the maximum effect being observed after 10 microg/side of the agonist.”

“In animals treated repeatedly with the psychostimulant, the behavioral response to a challenge dose of cocaine was dose-dependently increased when that drug was combined with CP 94,253, but not with GR 127935 + CP 94,253.”

“When rats were treated repeatedly with cocaine , a challenge dose of CP 94,253 produced an about threefold increase in the locomotor effect compared to the animals treated likewise with saline (Experiment 3).”

“Finally, when CP 55,940 (50 microg/kg) was co-administered with cocaine , it significantly reduced the locomotor hyperactivity produced by the drug but did not block the development of behavioral sensitization.”

“ Cocaine resulted in prolongation of an index of end-diastolic isovolumic relaxation time (τ) from a baseline of 34 milliseconds to 56 milliseconds … 15 minutes after cocaine administration in the control group and from a baseline of 35 milliseconds to 49 milliseconds in the captopril group (P<0.05).”