Possible Interaction: Captopril and Carrageenan

“It is concluded that inhibition of ACE by captopril enhanced the early production of endogenous BK and the edema formation induced by carrageenan through a B2 receptor-mediated mechanism.”

“Intraperitoneal administration of captopril (10 mg/kg) caused a marked reduction (by 98%) in levels of [1-5]BK in exudates 3 hr after administration of carrageenan.”

“2 Captopril , an inhibitor of kininase 2, increased the level of kinins and the volume of the exudates after carrageenin treatment.”

“1 Hind paw oedema in rats, measured by plethysmography or extravasation of Evans Blue dye into the skin, after subplantar injection of submaximal doses of carrageenin (1–100 μg) was significantly increased for 4 h during kininase II inhibition with captopril (1 mg kg−1, s.c.).”

“3 The pain threshold of the paw, injected with carrageenin (1 μg) was lowered significantly after subcutaneous administration of captopril (1 mg kg−1).”