Possible Interaction: Capsaicin and Tyrosine

“Notably, capsaicin augmented the phosphorylation of a phosphatase, PP2A at tyrosine 307 , suggesting its repression of the enzymatic activity of the phosphatase.”

“ Capsaicin also suppressed both basal and carbachol-stimulated 14C-catecholamine synthesis (IC50=10.6 and 26.4 μM, respectively) from [14C] tyrosine but not from l-3, 4-dihydroxyphenyl [3-14C] alanine ([14C] DOPA) as well as tyrosine hydroxylase activity (IC50=8.4 and 39.0 μM, respectively).”

“ Tyrosine , which seems to be the best preventive agent of capsaicin inhibitory effects, prevents its metabolism but not its diffusion.”

“Our previous studies have shown that capsaicin competitively inhibits the fixation of tyrosine on its specific tRNA catalysed by the tyrosyl-tRNA synthetase in a cell-free system.”

“Provided that this competitive action of tyrosine on the molecular mode of action of capsaicin is confirmed in other cells such as neurones, it could be speculated that capsaicin could disturb the synthesis of the catecholamines, neurotransmitters of the central nervous system deriving from tyrosine.”

“The inhibition of protein synthesis induced by capsaicin was prevented in a concentration-dependent manner by tyrosine.”