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Last Updated: 2 years ago

Possible Interaction: Capsaicin and Tetrodotoxin

supplement:

Capsaicin

Research Papers that Mention the Interaction

The effect of capsaicin was blocked by capsazepine (1 microM), TTX (100 nM) and KN-62 (1 microM), but not by K252a (200 nM) or PD98059 (50 microM) indicating the involvement of TRPV1.
Brain Research  •  2008  |  View Paper
TTX attenuates release of CGRP caused by low concentrations of capsaicin , indicating that an axon reflex mechanism in the peripheral endings of C-fibre afferents can augment local outflow of CGRP.
Scandinavian cardiovascular journal. Supplement  •  1998  |  View Paper
A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin.
Neuroscience Letters  •  1996  |  View Paper
CONCLUSIONS The combination of encapsulated te rodotoxin an d cap saicin ac hieved marked prolongation of nerve block.
Coadministration of capsaicin and tetrodotoxin , a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks.
Anesthesia and analgesia  •  2019  |  View Paper
Four combinations composed of various concentrations of loureirin B and capsaicin could all inhibit TTX-R sodium currents but have different interactions between loureirin B and capsaicin.
  •  2018  |  View Paper
The subcutaneous administration of TTX dose-dependently inhibited the number of pain-related behaviors in all evaluated pain models and reversed the referred mechanical hyperalgesia (examined by stimulation of the abdomen with von Frey filaments) induced by capsaicin and cyclophosphamide, but not that induced by mustard oil.
Marine drugs  •  2017  |  View Paper
In the presence of TTX, capsaicin increased the fluctuation of the membrane potential of the CO2-sensitive preinspiratory neurons in the parafacial respiratory group (pFRG), accompanied by slight depolarization.
Pflügers Archiv - European Journal of Physiology  •  2016  |  View Paper
At all developmental stages, TRPV1 activation with the selective agonist capsaicin increases glutamate release in the presence of tetrodotoxin , which blocks action potential-dependent and polysynaptic neurotransmission, indicating that functional TRPV1 fibers innervate SDCN neurons directly.
Molecular Neurobiology  •  2015  |  View Paper
CONCLUSION:The findings suggest that capsaicin decreases both TTX-s and TTX-r INa+ as a result of an increase in [Na+]i through TRPV1.
Anesthesia and analgesia  •  2011  |  View Paper
TTX (1 μM) largely (∼81.5%) blocked the effect of capsaicin.
Pain  •  2007  |  View Paper
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