supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“The effect of capsaicin was blocked by capsazepine (1 microM), TTX (100 nM) and KN-62 (1 microM), but not by K252a (200 nM) or PD98059 (50 microM) indicating the involvement of TRPV1.”
Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons“ TTX attenuates release of CGRP caused by low concentrations of capsaicin , indicating that an axon reflex mechanism in the peripheral endings of C-fibre afferents can augment local outflow of CGRP.”
“A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin.”
“CONCLUSIONS The combination of encapsulated te rodotoxin an d cap saicin ac hieved marked prolongation of nerve block.”
“Coadministration of capsaicin and tetrodotoxin , a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks.”
Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes.“Four combinations composed of various concentrations of loureirin B and capsaicin could all inhibit TTX-R sodium currents but have different interactions between loureirin B and capsaicin.”
“The subcutaneous administration of TTX dose-dependently inhibited the number of pain-related behaviors in all evaluated pain models and reversed the referred mechanical hyperalgesia (examined by stimulation of the abdomen with von Frey filaments) induced by capsaicin and cyclophosphamide, but not that induced by mustard oil.”
“In the presence of TTX, capsaicin increased the fluctuation of the membrane potential of the CO2-sensitive preinspiratory neurons in the parafacial respiratory group (pFRG), accompanied by slight depolarization.”
“At all developmental stages, TRPV1 activation with the selective agonist capsaicin increases glutamate release in the presence of tetrodotoxin , which blocks action potential-dependent and polysynaptic neurotransmission, indicating that functional TRPV1 fibers innervate SDCN neurons directly.”
“CONCLUSION:The findings suggest that capsaicin decreases both TTX-s and TTX-r INa+ as a result of an increase in [Na+]i through TRPV1.”
“ TTX (1 μM) largely (∼81.5%) blocked the effect of capsaicin.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback