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Last Updated: a year ago

Possible Interaction: Capsaicin and Sumatriptan

supplement:

Capsaicin

Research Papers that Mention the Interaction

Results DBF responses to capsaicin were attenuated by sumatriptan (ΔDBF, mean ± SEM: 82 ± 18 AU, p = 0.0002), but not by placebo (ΔDBF: 21 ± 12 AU, p = 0.1026).
Cephalalgia : an international journal of headache  •  2017  |  View Paper
However, remote hind limb and capsaicin preconditioning-induced cardioprotective effects were remarkably reduced in the presence of sumatriptan (8 mg/kg-1 ) and CGRP8-37 (1 mg/kg-1 ).
Cardiovascular therapeutics  •  2017  |  View Paper
sumatriptan (300-1000 microg) significantly inhibited the vasodilator responses to capsaicin , but not those to alpha-CGRP or acetylcholine.
European journal of pharmacology  •  2009  |  View Paper
These findings indicate that both local and systemic activation of the 5‐HT1B/D receptor by sumatriptan reduce NI induced by nerve stimulation or capsaicin presumably by inhibiting neuropeptide release.
completely blocked the inhibitory effect of sumatriptan on capsaicin‐induced vasodilation and reduced the inhibitory effect of sumatriptan on capsaicin and electrically induced‐PE.
Pain  •  2008  |  View Paper
Pierce et al were the first to report that high concentrations of sumatriptan exacerbated the extravasation produced by capsaicin – a reversal of the inhibition seen at lower concentrations.
Headache  •  2017  |  View Paper