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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Sumatriptan
Research Papers that Mention the Interaction
“Results DBF responses to capsaicin were attenuated by sumatriptan (ΔDBF, mean ± SEM: 82 ± 18 AU, p = 0.0002), but not by placebo (ΔDBF: 21 ± 12 AU, p = 0.1026).”
A human trigeminovascular biomarker for antimigraine drugs: A randomised, double-blind, placebo-controlled, crossover trial with sumatriptan“However, remote hind limb and capsaicin preconditioning-induced cardioprotective effects were remarkably reduced in the presence of sumatriptan (8 mg/kg-1 ) and CGRP8-37 (1 mg/kg-1 ).”
Exploring the putative role of TRPV1‐dependent CGRP release in remote hind preconditioning‐induced cardioprotection“ sumatriptan (300-1000 microg) significantly inhibited the vasodilator responses to capsaicin , but not those to alpha-CGRP or acetylcholine.”
“These findings indicate that both local and systemic activation of the 5‐HT1B/D receptor by sumatriptan reduce NI induced by nerve stimulation or capsaicin presumably by inhibiting neuropeptide release.”
“completely blocked the inhibitory effect of sumatriptan on capsaicin‐induced vasodilation and reduced the inhibitory effect of sumatriptan on capsaicin and electrically induced‐PE.”
“Pierce et al were the first to report that high concentrations of sumatriptan exacerbated the extravasation produced by capsaicin – a reversal of the inhibition seen at lower concentrations.”
Triptan‐Induced Sensitization of Trigeminovascular Sensation
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